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Email Correspondence with Dr. Anil D'Cruz, Director of Tata Memorial Sept-Oct 2010

(7 emails from him, 9 from me)

Subject:  Your letter dt. 09/09/2010
From:  "Dr. Anil K Dcruz" <dcruzak@tmc.gov.in>
Date:  Wed, September 29, 2010 12:54 am
To:  ajay@kulsh.com
Cc:  docdcruz@gmail.com

Dear Mr. Kulshrestha,

This is regards your letter dt. September 09, 2010 addressed to Dr. R.A. Badwe, Director, TMC regarding article "Targeting a Key Enzyme in Cell Growth: A Novel Therapy for Cancer". In this regard it will be nice to talk to you over telephone before making any decision. Kindly let us know your contact details.

Regards,
Dr. D'Cruz

A K Dcruz
Director Tata Memorial Hospital
Professor & Surgeon
Chief Head Neck Services
Tata Memorial Hospital
Parel Mumbai 400012
Tel 91-22-24177000
Fax 91-22-24158989

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On Wed, Sep 29, 2010 at 10:16 PM, <ajay@kulsh.com> wrote:

Dear Dr. D'Cruz,

I am currently in India in the city of Jaipur. You can reach me at 0-999-975-2036. Please call after 10 AM.

Normally I prefer electronics communication over phone since it is so easy to refer back to what was discussed and when. Of course, phone conversation has its own value and I look forward to talking to you. Thanks.

Sincerely,

Ajay K. Kulshreshtha

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On Wed, September 29, 2010 12:06 pm, "Anil D'Cruz" <docdcruz@gmail.com> wrote:

Ajay

No issues
Pl stay in touch via electronic communication
Would like to understand the nature and scope of the possible collaboration

Best
dr dcruz

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Subject:  Possible Collaboration on Gentle Electrotherapy for Cancer (targeting enzyme RR)
From:  ajay@kulsh.com
Date:  Thu, Sep 30, 2010 at 12:20 AM
To:  "Anil D'Cruz" <docdcruz@gmail.com>
Cc:  "Dr.D'Cruz-TMC" dcruzak@tmc.gov.in

Dear Dr. D'Cruz,

Gentle Electrotherapy for cancer is deductively scientific and has shown remarkable efficacy with animal models (see enclosed article), as well as with a few human subjects who have been treated by my device. It is also non-toxic.

In my proposed collaboration, this therapy would be offered at TMC to patients with near-surface tumors:
1. whose tumors have stopped responding to chemo and radiotherapies.
2. who are too old to endure chemo or radiotherapies.
3. whose tumors, because of their location, are unsuited to be treated by any of the conventional treatments.

By the way, the cost of this treatment will be less than that of other therapies.

You likely have many questions for me. I look forward to hearing from you. Thanks.

Sincerely,

Ajay K.

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On Thu, September 30, 2010 4:55 am, "Anil D'Cruz" docdcruz@gmail.com wrote:

Is this similar to electroporation
Is this suggestion for a protocol
If yes send me the CDA and the protocol and will consider to take this forward

regards
dr dcruz

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On Thu, September 30, 2010 11:30 am, <ajay@kulsh.com wrote:

Dear Dr. D'Cruz,

The similarity between Gentle Electrotherapy to Inhibit Pivotal Enzyme (sometimes called GEIPE) and Electroporation is minimal. Both involve electricity but modalities and objectives are quite different. As I understand it, in Electroporation, short-and-intense electric pulses are used to deliver drugs or genes into the cell. While in GEIPE, we use low voltage (less than 7V) to pass direct current in milli-ampere range thru tissue over a long period; no drug is involved.

CDA or Clinical Document Architecture has various implementations or formats. Please send me guidelines (Titles and sub-titles, if any, of various sections) for the CDA that is standard at TMC. I will complete the CDA and send protocol details of the Gentle Electrotherapy for cancer.

Thanks.

Sincerely,

Ajay K.

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On Tue, October 5, 2010 10:53 am, <ajay@kulsh.com wrote:

Dear Dr. D'Cruz,

I have not heard from you in many days. I understand you have a busy schedule but may I expect a response sometimes this week?

Just to reiterate the importance of enzyme Ribonucleotide Reductase, there are 4 classes of anti-cancer chemo drugs that fall in the family of "Ribonucleotide Reductase Inhibitors":

-- motexafin gadolinium
-- hydroxyurea
-- fludarabine, cladribine, gemcitabine, tezacitabine, and triapine
-- gallium maltolate, gallium nitrate

My proposed electrotherapy inhibits this enzyme without any toxic side-effects.

I look forward to hearing from you. Thanks.

Ajay K.

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On Tue, October 5, 2010 11:19 am, "Anil D'Cruz" docdcruz@gmail.com wrote:

i don't think i recd your last mail and hence no reply
Your concept sounds interesting
I look forward to discussing with you the possibility of taking this to the next step
Which cancers do you envisage will benefit the most of this treatment
Would you like to work this out in a trial setting

Do let me know

dr dcruz

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On Wed, Oct 6, 2010 at 11:51 AM, <ajay@kulsh.com> wrote:

Dear Dr. D'Cruz,

GEIPE therapy is most suited for tumors which are at or near -- within a few centimeters -- of the surface. Thus most cancers in facial area, including those inside the mouth, should be suitable. (All 4 treated
patients whose photos I included with the letter had such tumors.)

Yes, this therapy needs to be systematically studied in a trial setting. I can fill the details of the proposal once you provide me the guidelines. Thanks.

Ajay K.

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On Thu, October 7, 2010 5:53 am, "Anil D'Cruz" docdcruz@gmail.com wrote:

Sounds good
If you could send me a synopsis of the trial I could present it in our DMG
Once accepted we can then make the submission to our IRB
If agreeable pl do send it at the earliest

regards
dr dcruz

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On Fri, October 8, 2010 3:26 am, <ajay@kulsh.com> wrote:

Dear Dr. D'Cruz,

Please give me 2-3 days to prepare the document. Thanks.

Ajay K.

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On Fri, October 8, 2010 4:55 am, "Anil D'Cruz" docdcruz@gmail.com wrote:

Done
Am out of mumbai Monday thru Friday night
dr dcruz

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Subject: 2-page Proposal for GEIPE clinical trials
On Sun, October 10, 2010 4:53 am, <ajay@kulsh.com> wrote:


Dear Dr. D'Cruz,

Enclosed please find a 2-page proposal for GEIPE clinical trials. It is a bit more than a synopsis and you can trim it as you see fit.

I look forward to hearing from you after you are back in town and present the proposal to your DMG. Thanks.

Ajay K.

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On Sat, October 23, 2010 7:41 am, <ajay@kulsh.com> wrote:

Dear Dr. D'Cruz,

During this week, I hope you have had time to review the proposal I had sent for GEIPE trials. When might you present it in your meeting? Please update me. Thanks.

Ajay K.

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On Sat, October 23, 2010 9:08 am, "Anil D'Cruz" docdcruz@gmail.com wrote:

Dear Ajay

Am tied up till Monday
Our hospital is in the midst of a peer review process
Remind me early next week

Regards
dr dcruz

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On Tue, October 26, 2010 9:49 am, <ajay@kulsh.com> wrote:

Dear Dr. D'Cruz,

Per your suggestion, I am reminding you about presenting my proposal. Thanks.

Ajay

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Subject:  Status of the Proposal for GEIPE clinical trials?
From:  ajay@kulsh.com
Date:  Tue, November 2, 2010 4:40 am
To:  "Dr.D'Cruz-TMC" <dcruzak@tmc.gov.in>
Cc:  "Anil D'Cruz" <docdcruz@gmail.com>
Read receipt: requested

Dear Dr. D'Cruz,

I have not heard from you in about a week. Please update me of the status. Thanks.

Ajay K.

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