|
Subject: Your letter dt. 09/09/2010
From: "Dr. Anil K Dcruz" <dcruzak@tmc.gov.in>
Date: Wed, September 29, 2010 12:54 am
To: ajay@kulsh.com
Cc: docdcruz@gmail.com
Dear Mr. Kulshrestha,
This is regards your letter dt. September 09, 2010 addressed to Dr. R.A. Badwe, Director,
TMC regarding article "Targeting a Key Enzyme in Cell Growth: A Novel Therapy for Cancer".
In this regard it will be nice to talk to you over telephone before making any decision.
Kindly let us know your contact details.
Regards,
Dr. D'Cruz
A K Dcruz
Director Tata Memorial Hospital
Professor & Surgeon
Chief Head Neck Services
Tata Memorial Hospital
Parel Mumbai 400012
Tel 91-22-24177000
Fax 91-22-24158989
----------------------------------------------
On Wed, Sep 29, 2010 at 10:16 PM, <ajay@kulsh.com> wrote:
Dear Dr. D'Cruz,
I am currently in India in the city of Jaipur. You can reach
me at 0-999-975-2036. Please call after 10 AM.
Normally I prefer
electronics communication over phone since it is so easy to refer back to
what was discussed and when. Of course, phone conversation has its own value
and I look forward to talking to you. Thanks.
Sincerely,
Ajay K. Kulshreshtha
----------------------------------------------
On Wed, September 29, 2010 12:06 pm, "Anil D'Cruz" <docdcruz@gmail.com> wrote:
Ajay
No issues
Pl stay in touch via electronic communication
Would like to
understand the nature and scope of the possible collaboration
Best
dr dcruz
----------------------------------------------
Subject: Possible Collaboration on Gentle Electrotherapy for Cancer (targeting enzyme RR)
From: ajay@kulsh.com
Date: Thu, Sep 30, 2010 at 12:20 AM
To: "Anil D'Cruz" <docdcruz@gmail.com>
Cc: "Dr.D'Cruz-TMC" dcruzak@tmc.gov.in
Dear Dr. D'Cruz,
Gentle Electrotherapy
for cancer is deductively scientific and has shown remarkable efficacy with
animal models (see enclosed article), as well as with a few human subjects
who have been treated by my device. It is also non-toxic.
In my
proposed collaboration, this therapy would be offered at TMC to patients
with near-surface tumors:
1. whose tumors have stopped responding to
chemo and radiotherapies.
2. who are too old to endure chemo or
radiotherapies.
3. whose tumors, because of their location, are unsuited
to be treated by any of the conventional treatments.
By the way, the
cost of this treatment will be less than that of other therapies.
You
likely have many questions for me. I look forward to hearing from you.
Thanks.
Sincerely,
Ajay K.
----------------------------------------------
On Thu, September 30, 2010 4:55 am, "Anil D'Cruz" docdcruz@gmail.com wrote:
Is this similar to electroporation
Is this suggestion for a protocol
If yes send me the CDA and the protocol and will consider to take this
forward
regards
dr dcruz
----------------------------------------------
On Thu, September 30, 2010 11:30 am, <ajay@kulsh.com wrote:
Dear Dr. D'Cruz,
The similarity between Gentle Electrotherapy to Inhibit
Pivotal Enzyme (sometimes called GEIPE) and Electroporation is minimal. Both
involve electricity but modalities and objectives are quite different. As I
understand it, in Electroporation, short-and-intense electric pulses are
used to deliver drugs or genes into the cell. While in GEIPE, we use low
voltage (less than 7V) to pass direct current in milli-ampere range thru
tissue over a long period; no drug is involved.
CDA or Clinical
Document Architecture has various implementations or formats. Please send me
guidelines (Titles and sub-titles, if any, of various sections) for the CDA
that is standard at TMC. I will complete the CDA and send protocol details
of the Gentle Electrotherapy for cancer.
Thanks.
Sincerely,
Ajay K.
----------------------------------------------
On Tue, October 5, 2010 10:53 am, <ajay@kulsh.com wrote:
Dear Dr.
D'Cruz,
I have not heard from you in many days. I understand you have
a busy schedule but may I expect a response sometimes this week?
Just
to reiterate the importance of enzyme Ribonucleotide Reductase, there are 4
classes of anti-cancer chemo drugs that fall in the family of
"Ribonucleotide Reductase Inhibitors":
-- motexafin gadolinium
--
hydroxyurea
-- fludarabine, cladribine, gemcitabine, tezacitabine, and
triapine
-- gallium maltolate, gallium nitrate
My proposed
electrotherapy inhibits this enzyme without any toxic side-effects.
I
look forward to hearing from you. Thanks.
Ajay K.
----------------------------------------------
On Tue, October 5, 2010 11:19 am, "Anil D'Cruz" docdcruz@gmail.com wrote:
i don't think i recd your last mail and hence no reply
Your concept
sounds interesting
I look forward to discussing with you the possibility of taking this to
the next step
Which cancers do you envisage will benefit the most of this treatment
Would you like to work this out in a trial setting
Do let me know
dr dcruz
----------------------------------------------
On Wed, Oct 6, 2010 at 11:51 AM, <ajay@kulsh.com> wrote:
Dear Dr.
D'Cruz,
GEIPE therapy is most suited for tumors which are at or near
-- within a few centimeters -- of the surface. Thus most cancers in facial
area, including those inside the mouth, should be suitable. (All 4 treated
patients whose photos I included with the letter had such tumors.)
Yes, this therapy needs to be systematically studied in a trial setting. I
can fill the details of the proposal once you provide me the guidelines.
Thanks.
Ajay K.
----------------------------------------------
On Thu, October 7, 2010 5:53 am, "Anil D'Cruz" docdcruz@gmail.com wrote:
Sounds good
If you could send me a synopsis of the trial I could
present it in our DMG
Once accepted we can then make the submission to
our IRB
If agreeable pl do send it at the earliest
regards
dr
dcruz
----------------------------------------------
On Fri, October 8, 2010 3:26 am, <ajay@kulsh.com> wrote:
Dear Dr.
D'Cruz,
Please give me 2-3 days to prepare the document. Thanks.
Ajay K.
----------------------------------------------
On Fri, October 8, 2010 4:55 am, "Anil D'Cruz" docdcruz@gmail.com wrote:
Done
Am out of mumbai Monday thru Friday night
dr dcruz
----------------------------------------------
Subject: 2-page Proposal for GEIPE clinical trials
On Sun, October 10,
2010 4:53 am, <ajay@kulsh.com> wrote:
Dear Dr. D'Cruz,
Enclosed please find a 2-page proposal for GEIPE clinical trials. It is a
bit more than a synopsis and you can trim it as you see fit.
I look
forward to hearing from you after you are back in town and present the
proposal to your DMG. Thanks.
Ajay K.
----------------------------------------------
On Sat, October 23, 2010 7:41 am, <ajay@kulsh.com> wrote:
Dear Dr. D'Cruz,
During this week, I hope you have had time to review the
proposal I had sent for GEIPE trials. When might you present it in your
meeting? Please update me. Thanks.
Ajay K.
----------------------------------------------
On Sat, October 23, 2010 9:08 am, "Anil D'Cruz" docdcruz@gmail.com wrote:
Dear Ajay
Am tied up till Monday
Our hospital is in the midst
of a peer review process
Remind me early next week
Regards
dr
dcruz
----------------------------------------------
On Tue, October 26, 2010 9:49 am, <ajay@kulsh.com> wrote:
Dear Dr.
D'Cruz,
Per your suggestion, I am reminding you about presenting my
proposal. Thanks.
Ajay
----------------------------------------------
Subject: Status of the Proposal for GEIPE clinical trials?
From: ajay@kulsh.com
Date: Tue, November 2, 2010 4:40 am
To: "Dr.D'Cruz-TMC" <dcruzak@tmc.gov.in>
Cc: "Anil D'Cruz" <docdcruz@gmail.com>
Read receipt: requested
Dear Dr. D'Cruz,
I have not heard from you
in about a week. Please update me of the status. Thanks.
Ajay K.
----------------------------------------------
----------------------------------------------
Back to
1st Letter of Tata Memorial or
Inaction of Cancer Institutes page or Home page of
Breakthrough Cancer Treatment
◊
GEIPE Cancer Therapy
|