Jay Kulsh’s 1994 letter answering objections of UCLA Cancer Center

May 27, 1994

Dr. H. Rodney Withers - Director
UCLA Jonsson Comprehensive Cancer Center
10833 Le Conte Ave.
Los Angeles, CA 90024

Dear Dr. Withers,

Thank you for your letter dated May 20, 1994. Your decision of not committing resources to low-level DC electrotherapy may be correct and proper, but I do wish to respond to the objections raised by you:

1. It is true that negative results are infrequently published, but this is unlikely to be the case here since the last paper published (in 1992) on this subject -- ref.#6 on the yellow sheet -- was all negative. [A careful study of the previous works would indicate that most beneficial results are obtained with 2 to 3 milli-ampere currents applied at 1.5 to 3 volts. Authors of the last paper, however, decided to use 20 mA at 9 V, causing electrochemistry rather than electrotherapy!]

2. Yes, electric currents are used to heal bone-fractures but such currents are usually alternate. Even when direct currents are used for this purpose, the level is kept between 2 and 20 micro-ampere -- about 100 to 1000 times less than that suitable for tumor-treatment.

3. I am a bit surprised at your statement that the tumor systems used in those publications would have elicited immune rejection responses and hence the results are open to some question. In all the experiments, comparative studies were done between test and control groups. Since immune system would affect both groups equally, it should have no bearing on (differential) results.

4. Low-level DC electrotherapy may act selectively on a tumor since its likely target is the free-radical containing active-site of enzyme ribonucleotide reductase. Concentration of this enzyme - vital for cell growth - is exponentially higher in cancerous cells, as compared to ordinary cells. (In fact, basal level concentration of this enzyme in normal cells is so low that it can only be inferred, not detected.) Evidence seems to indicate that feeble direct currents of a few milliampere have little, if any, adverse effect on healthy tissues. This is in contrast with chemotherapeutic drugs - including hydroxy urea - which often destroy biochemical machinery of a cell at multiple sites, without any finesse, and thus are highly toxic to all tissues.


Signature of Jay Kulsh

Jay Kulsh

1333 N. Sweetzer Ave. #2F, Los Angeles, CA 90069 * Phone/Fax: 213-654-3782

P.S.: Recently-retired Dr. Robert 0. Becker - a top authority in the field of bioelectricity -who in his last book 'Cross Currents' mentioned about the need for "a more sophisticated approach" in treating cancer with electricity, thinks that I have right ideas.